Symbol
Name
ID

Vhl
von Hippel-Lindau tumor suppressor
MGI:103223

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cerebral hemorrhage	Increased hematocrit	Increased circulating hemoglobin concentration	Polycythemia	Increased red blood cell mass	Peripheral thrombosis	Hepatosplenomegaly
Disease(s) Associated with VHL	Cerebral hemorrhage	Increased hematocrit	Increased circulating hemoglobin concentration	Polycythemia	Increased red blood cell mass	Peripheral thrombosis	Hepatosplenomegaly
familial erythrocytosis 2
pancreatic cancer
pheochromocytoma
von Hippel-Lindau disease

Mouse Phenotypes

hematopoietic system phenotype

enlarged spleen

increased spleen weight

abnormal blood cell morphology/development

abnormal common myeloid progenitor cell morphology

abnormal erythropoiesis

extramedullary hematopoiesis

decreased bone marrow cell number

increased megakaryocyte cell number

increased erythroid progenitor cell number

increased erythrocyte cell number

polycythemia

increased hematocrit

increased hemoglobin content

decreased lymphocyte cell number

increased leukocyte cell number

reticulocytosis

increased hematopoietic stem cell number

abnormal spleen morphology

increased spleen red pulp amount

decreased spleen white pulp amount

Availability

Mouse Genotype

Vhl^tm1Mcs/Vhl^tm1Mcs

Vhl^tm1Jae/Vhl^tm1Jae
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Hprt1^{tm1(Pck1-cre)Vhh}/Y
Vhl^tm1Jae/Vhl^tm1Jae (conditional)

Vhl^tm1Jae/Vhl^tm1Jae
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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